Expert synthetic chemists amplified by state-of-the-art automation
There are times when inhouse synthetic chemistry simply can’t meet the demand, XtalPi’s Amplified Chemical Synthesis service can become your auxiliary team - our expert synthetic chemists stand ready to discuss your synthesis needs and challenges, and will work collaboratively with you to design the best strategy forward.
Through significant capital investment in state-of-the-art robotics, and because common reactions in medicinal chemistry are well established, our 200 workstations can easily handle routine reactions, perform parallel as well as multi-step syntheses. Automation thus liberates our experienced chemists to focus on interesting new chemistries and unique challenges that come up in trying to synthesize novel compounds.
Beyond the obvious amplification of synthetic throughput, automation also ensures standardization and eliminates human error, resulting in dramatically accelerated syntheses and higher-quality products.
Specific Solutions
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Conventional Medicinal Chemistry
High-quality compound synthesis from milligram to kilogram
Design and exploration of new synthetic routes
Molecular block synthesis
Screening and optimization of reaction conditions
Compound library synthesis
Catalyst screening
Synthesis of APIs and intermediates
Custom compositing
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Specialty Chemistry
Non-traditional medicinal chemistry synthesis
Peptides
DEL
Photochemistry
PROTAC
Metal organic chemistry
ADC
Isotopic labeling chemistry
Macrocyclic compounds
Advantages
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Experienced Scientists
>50% with advanced degree
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Brand New Facilities
Automation stations to accelerate and standardize procedures
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AI and Automation
AI to optimize synthetic route design
High-throughput experiments through automation
Reproducible and standardized results
Parallel synthesis
Multi-step reactions
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State-of-the-art Instrumentation
NMR: Bruker 400MHz
LC-MS: Agilent ; Waters; Shimadzu
Prep HPLC: Gilson ; Shimadzu
CombiFlash: Biotage
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Comprehensive Management
Laboratory management
Compound management
IP management and IT security support
EHS training and inspection
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Flexible Collaboration
Full-time Service Model (FTE)
Customized Service Model (FFS)
Assay laboratory
Synthesis laboratory
Synthesis laboratory2
NMR（Bruker）
XtalPi is keenly aware that every research partner has unique needs and priorities, and is happy to create a customized solution to optimize your research program
